Search for crossword clues found in the Daily Celebrity, NY Times, Daily Mirror, Telegraph and major publications. 8% of all craniosynostoses []. It is the most common form of craniosynostosis. Compared with wild-type, Crouzon (FGFR2 C342Y/+) maxillae were significantly shorter in maximum height, anterior and posterior lengths and middle width, but larger in posterior width (p < 0. Crouzon syndrome shares many of the same features. Answer of Figgerits Crouzon syndrome results in lower jaw __: PROTRUSION. bin chicken (4) Crossword Clue. Bulging, wide-set eyes. Enter a Crossword Clue. Crouzon syndrome should be managed as early as possible as it results in impaired facial appearance and other complications like mental retardation, airway obstruction, and decreased visual acuity as the patient gets older. Maxillary hypoplasia. Most cases are sporadic, but autosomal dominant inheritance has been reported ( Mantilla-Capacho et al. Specifically, this syndrome affects the first branchial (or pharyngeal) arch, which is the precursor of the maxilla and mandible. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Lower jaw is a crossword clue for which we have 1 possible answer and we have spotted 5 times in our database. Described by a French neurosurgeon in 1912, it is a rare genetic disorder. Showing typical extraoral characteristics of Crouzon syndrome, the patient had a frontal and left-sided. Oral surgery: to align the teeth of the upper and lower jaws. The primary ocular features result from pattern-specific, premature synostoses of cranial sutures. Like so many other craniofacial conditions, Crouzon syndrome is highly variable across cases; some people are mildly affected, while others have a more severe presentation. In the 1990s, for example, they learned that a mutation in one gene causes Crouzon syndrome — characterized by wide-set, often bulging eyes and an underdeveloped upper jaw — while a mutation. Crouzon Syndrome is characterised by a premature fusing of certain skull bones during the fourth week of development; specifically affecting the lower jaw bone and the palate. Crouzon syndrome with acanthosis nigricans is a rare genetic condition. benefit. The bones around the eyes (orbits) are wider spaced and shallower than usual, causing the eyes to bulge outwards. Of course, sometimes there’s a crossword clue that totally stumps us, whether it’s because we are unfamiliar with the. Strip craniotomy with SAE has resulted in successful outcomes with low complication and revision rates in patients with isolated scaphocephaly. Orthognathic surgery is the standard form of surgery to move either the upper or lower jaw into proper alignment. Crouzon Syndrome is a genetic disorder marked by the premature fusion of certain skull bones during a child's development. Craniofacial developmental anomalies are the most common source of birth defects in humans, present in 1 out of 700 births [1–3]. Sporadic cases of Crouzon’s syndrome has been associated with advanced paternal age. This process is called craniosynostosis. wide-set, bulging eyes. The Crossword Solver found 30 answers to "Upper fixed bone of the jaw (7)", 7 letters crossword clue. Result - crossword puzzle clues and possible answers. The aim of this study was to report on a single center’s experience with spring-assisted cranial vault expansion (SAE) in patients with Crouzon syndrome and sagittal suture synostosis. Crouzon syndrome is one of the most common craniosynostosis facial syndromes caused by a mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. Crouzon syndrome. 8% of all cases of craniosynostosis. Symptoms of Crouzon Syndrome. twist. Craniofacial anomalies are among the most common of birth defects. Prenatal diagnosis was performed on the high-risk f. dangerous eye drying that can occur in Apert syndrome. Crouzon’s syndrome is caused by mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. GARD: 19 Crouzon syndrome is a disorder characterized by early fusion of certain skull bones (craniosynostosis). The disorder is characterized by distinctive malformations of the skull and facial (craniofacial) region. The palate is often high and arched. 5/1,000,000, accounting for 4. Click the answer to find similar crossword clues . scold. The patient was referred to pediatrician for detailed examination and confirmation of diagnosis. Enter the length or pattern for better results. Enter a Crossword Clue. Crouzon syndrome is characterized by craniosynostosis and facial dysostosis with an incidence of 16. It involves the premature fusion of sutures of the cranial vault. It occurs in one of every 25,000 births. Crouzon syndrome is an autosomal dominant disorder characterized by craniosynostosis causing secondary alterations of the facial bones and facial structure. It is the most common form of craniosynostosis. ) New mutation – 25 to 50% of cases (Head, 2010) Autosomal Dominant (Crouzon syndrome, 2010) 50% probability of transfer to offspring. The most common craniosynostosis syndromes are Crouzon, Pfeiffer and Apert. Cycloplegic refraction was +1. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. , 2000). Many features of Crouzon syndrome result from the premature fusion of the skull bones. Pierre Robin sequence (PRS) is a craniofacial disorder characterized in part by a small lower jaw and caused by a mutation in the regulatory gene. Mandible distraction starts with surgery to make a cut on both sides of the lower jaw. This is a genetic syndrome that causes the seams of your skull to fuse abnormally. Children with Van der Woude Syndrome have lower lip pits (mound of tissue with hole in center) and cleft lip, cleft palate or both. We have the answer for Tip of lower jaw crossword clue in case you’ve been struggling to solve this one! Crosswords can be an excellent way to stimulate your brain, pass the time, and challenge yourself all at once. Underdeveloped upper jaw with a sunken facial appearance (maxillary or midface hypoplasia) Protrusion of the lower jaw (mandibular prognathism)A few individuals with Crouzon syndrome have an opening in the lip and the roof of the mouth (cleft lip and palate). Less commonly, it is caused due to mutated FGFR3 genes. embellish. Crouzon syndrome is the most common of the craniosynostosis syndromes. The hallmarks of Crouzon syndrome are overcrowding of upper and lower teeth, V-shaped maxillary dental arch, and bulging mandible (lower jaw). In 1912, a French neurologist Octave Crouzon was the first to describe Crouzon syndrome. Additionally, this disorder may present with premature fusion of multiple sutures, maxillary hypoplasia, and shallow orbits. 4:1 has been reported. loyal. Crouzon syndrome is a genetic problem. 5% respectively (p < 0. Crouzon syndrome with acanthosis nigricans has an estimated prevalence of 1 per 1,000,000 newborns. The manifestations of Crouzon syndrome result from the premature fusion of superior and posterior sutures of the maxilla. Answers for The protruding part of the lower jaw (4) crossword clue, 4 letters. Crouzon syndrome is a disorder characterized by early fusion of certain skull bones (craniosynostosis). 4. Enter a Crossword Clue. Crouzon syndrome is an autosomal dominant genetic condition. This syndrome has been associated with a variety of amino acid point mutations in the extracellular domain of fibroblast growth factor receptor 2. The Crossword Solver found 30 answers to "point of the jaw (4)", 4 letters crossword clue. The syndrome was first described in 1912 by French physician Octave Crouzon when he identified both a mother and daughter with what was originally. Click the answer to find similar crossword clues . Severity of the syndrome varies from mild to severe among individuals. Not the regular crosswords with the same graphics and gameplay, but a new way. Summarize the treatment of Crouzon syndrome. This is the answer to the clue : Crouzon syndrome results in lower jaw __ Figgerits. The Crossword Solver found 30 answers to "front of lower jaw (4)", 4 letters crossword clue. There are related clues (shown below). Pack Of Schemers Crossword Clue; The "S" Of 53 Down: Abbr Crossword Clue; Ratio (Tv Screen Metric) Crossword Clue; Playwright's Aphorism Enthralling Hearts Crossword Clue; Continuous Exercise Almost Causes Stroke Crossword Clue; Ascot, E. com. Enter a Crossword Clue. Crouzon syndrome is a rare genetic disorder. Click the answer to find similar crossword clues . We will try to find the right answer to this particular crossword clue. Crouzon syndrome. Enter a Crossword Clue. 1 Definition . Affected individuals often have a prominent forehead (frontal bossing); a curved nose; unusually flat or underdeveloped mid-facial regions (midface hypoplasia);. Enter the length or pattern for better results. His eye sockets were shallow causing the eyes to appear very bulging. Crouzon syndrome is a genetic disorder characterized by premature fusion of the skull bones (craniosynostosis) and abnormal growth of the bones of the face, specifically the eye sockets and the midface. Sometimes symptoms may be more severe in babies than in others. Enter the length or pattern for better results. Abstract. disgrace. Enter a Crossword Clue. We have 17. 6 people in every 100,000 and is caused by a genetic. Phenotypic expression in humans exhibits an autosomal dominant pattern that commonly involves premature fusion of the coronal suture (craniosynostosis) and severe midface. Please remember that I’ll always mention the master topic of the game :. The Crouzon syndrome is named after the French neurologist, Octave Crouzon, who described this disorder [1–3] which includes a triad of skull deformities, facial anomalies, and an exopthalmus [4, 5]. CASE REPORT. Showing typical extraoral characteristics of Crouzon. Nearly one quarter of craniosynostosis has a genetic aetiology [3,4]; there isCrouzon syndrome is characterized by craniosynostosis and facial dysostosis with an incidence of 16. 5 years, and the mean age at the last hearing test was 8. In this case full orthodontic pre-surgical preparation with fixed appliances was carried out. Premature fusion of the skull bones prevents the skull from growing normally and affects the shape of the child’s head and face. Enter a Crossword Clue. Material and methods. Additionally, patients with this syndrome have a higher, more. Last Seen Crosswords. Crouzon syndrome is a rare genetic disorder that is caused by mutations in the F ibroblast G rowth F actor R eceptor (FGFR)-2 and -3 genes, which are located on chromosome 10. The Crossword Solver found 30 answers to "lower jaw", 8 letters crossword clue. This surgery involves cutting and repositioning the upper jaw to improve how the jaws and the teeth fit together. The most common craniosynostosis syndromes are Crouzon, Pfeiffer and Apert. His parents are General Physicians practicing in Iraq. Simak penjelasan selengkapnya mengenai gejala, penyebab, hingga cara. Crouzon Syndrome Definition. The aim of this study was to explore the difference in maxillary and mandibular morphology and spatial position in Asian and Caucasian Crouzon syndrome patients. Abstract. Introduction. Crossword Solver > Clues > Crossword-Clue: Jaw. This pituitary gland condition occurs when your body makes too much growth hormone. This produces prominent, staring eyes. Pack Of Schemers Crossword Clue; The "S" Of 53 Down: Abbr Crossword Clue; Ratio (Tv Screen Metric) Crossword Clue; Playwright's Aphorism Enthralling Hearts Crossword Clue; Continuous Exercise Almost Causes Stroke Crossword Clue; Ascot, E. Infants have sutures between the bones in the face and skull. Treacher Collins syndrome is a genetic birth disorder characterized by the premature joining of certain bones of the skull during development, which affects the shape of the head and face. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. 3. mutation in FGFR3 genes results in Crouzon syndrome with acanthosis nigricans. Crouzon syndrome: (craniofacial dysostosis type 1 [CFD1]; Crouzon craniofacial dysostosis; Crouzon disease). This case report illustrates a temporally coordinated therapy plan that succeeds in reducing the burden of care. See more answers to this puzzle’s clues. For this study we used an established model of Crouzon syndrome. This syndrome is due to a specific mutation in FGFR3 gene that can be identified by genetic testing. Meet our team at UPMC Children's Hospital of Pittsburgh's Cleft-Craniofacial Center and learn about our treatment options, or contact UPMC Children's Hospital of Pittsburgh at 412-692-8650. Relating to the jaw (7) Crossword Clue. We found 20 possible solutions for this clue. Enter a Crossword Clue. The Crossword Solver found 30 answers to "canines in the upper jaw (3 5)", 8 letters crossword clue. Clinical reports regarding the entire surgical sequence in Crouzon syndrome from the neonatal period to the adult age are rare. Crouzon syndrome primarily involves the musculoskeletal system of the body, which includes bones, muscles, joints, and cartilage. Patients present with variable expression of the gene but appearance is characterized by protruding eyes (exorbitism), a result of the. Enter the length or pattern for better results. Crouzon, in 1912. Learn more from Boston Children's Hospital. Solve your "lower jaw" crossword puzzle fast & easy with the-crossword-solver. This can result in wide-set, bulging eyes. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Some of these genes may also be involved in Pfeiffer syndrome. Sleep apnea or difficulty breathing. Crouzon's Syndrome is a rare genetically inherited disorder with an incidence rate of 1 in 60,000 newborns worldwide. It can lead to enlarged tissues, such as an oversized jaw. The diagnosis of Crouzon syndrome and treatment of these patients are left to a few specialized centers and often challenge even experienced practitioners. Crouzon syndrome is considered as one of the most common craniosynostosis syndromes with a prevalence of 1 in 65,000 individuals, and has a close relationship with variants in fibroblast growth factor receptor 2. We told the causes of crouzon syndrome then we will also tell you what’s the available treatment. point of the jaw (4) Crossword Clue. There are other effects of this condition and ways to manage. Discussion. We will try to find the right answer to this particular crossword clue. Common features include hypertelorism, exophthalmos and external strabismus, parrot-beaked nose, short upper lip, hypoplastic maxilla, and a relative mandibular prognathism (Reardon et al. There are related clues (shown below). This prevents normal growth of the skull, which can affect the shape of the head and face. FGFR3 mutations in Crouzon syndrome with acanthosis nigricans result in the abnormal activation of the protein produced by the gene. Crouzon syndrome, also known as craniofacial dysostosis, is a complex genetic birth disorder that may affect a child’s face, skull, and teeth. Craniosynostosis, or premature fusion of the cranial sutures, is the basic identifiable characteristic of a patient who has Crouzon syndrome (sometimes called craniofacial dysostosis). A mutation in these genes may cause bones in the skull to fuse too early. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. See full list on my. Crouzon syndrome (OMIM: 123500) is caused by mutations in FGFR2, mapped to chromosome locus 10q26. Signs and symptoms of Crouzon syndrome may include wide-set, bulging eyes; strabismus (misalignment of the eyes); a small, "beak-shaped" nose. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Enter a Crossword Clue. Crouzon syndrome is a genetic condition, caused by a mutation (change) on a specific gene. 4. Crouzon syndrome is one of the most common craniosynostosis facial syndromes caused by a mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. The condition was named after a neurologist. Crouzon’s syndrome. Results. In children with a craniosynostosis syndrome, bones that fuse prematurely in the skull result in abnormal head shapes. All solutions for "jaw" 3 letters crossword answer - We have 5 clues, 79 answers & 115 synonyms from 3 to 18 letters. eye or jaw (5)", 5 letters crossword clue. Without the typical ossification of the sutures in the first year of life, the diagnosis of Crouzon syndrome may be delayed, as in this case. Deciduous canines and the left lateral incisor were present in the lower jaw, and the permanent canines, the left lateral incisor, and the lower right third molar were impacted. This study aims to conduct a comprehensive clinical and genetic investigation on a large family with members having various phenotypes, including acromesomelic dysplasia, type Maroteaux (AMDM), idiopathic short stature (ISS), Crouzon syndrome (CS). It was last seen in The LA Times quick crossword. Symptoms. Van der Woude Syndrome This syndrome is caused by a mutation in the IRF6 gene and is a common inherited form of cleft lip and/or palate (opening in the lip and/or the roof of the mouth). Crouzon syndrome is an autosomal dominant condition primarily characterized by craniosynostosis. Johnson, MA; Publication Type: Condition. Apert syndrome is a congenital disorder characterized primarily by craniosynostosis, midface hypoplasia, and syndactyly of the hands and feet with a tendency to fusion of bony structures. shallow eye socket, which may lead to. All solutions for "lower jaw" 8 letters crossword answer - We have 2 clues, 5 answers & 3 synonyms from 4 to 8 letters. Differential diagnosis of Crouzon’s. Fish with an elongated jaw Crossword Clue. Since the branchial arches are important developmental features in a growing embryo, disturbances in their development. The Crossword Solver found 30 answers to "Jaw cheek (4)", 4 letters crossword clue. igenetics also plays an important role in Crouzon syndrome [2,4]. Causes. JAW, lower (60%) JAW part (60%) jaw muscle (60%) jaw bone (60%. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. igenetics also plays an important role in Crouzon syndrome [2,4]. The bones in the skull and face join in the wrong way. Cranial malformation in Crouzon’s syndrome depends on the order and rate or progression of sutural synostosis. 3% in hair roots to 14. It was first described by the French neurosurgeon Dr. Enter the length or pattern for better results. Crouzon syndrome is a genetically inherited syndrome characterized by craniosynostosis (premature fusion of coronal sutures) resulting in the skull and facial deformities. 2 Narrow, high, or cleft palate and bifid. Enter the length or pattern for better results. Treacher Collins syndrome [], Apert syndrome [] and Crouzon syndrome [6,7]), the developmental genetics of complex. concave profile with an asymmetric mandibular jaw line. overcrowding of upper and lower teeth, and V-shaped maxillary dental arch. This syndrome affects around 5% of all the babies that have craniosynostosis. The bones around the eyes (orbits) are wider spaced and shallower than usual, causing the eyes to bulge outwards. Enter a Crossword Clue. This means premature fusion of the fibrous joints (called. Click the answer to find similar crossword clues . concave profile with an asymmetric. Search for crossword clues found in the Daily Celebrity, NY Times, Daily Mirror, Telegraph and major publications. Clue: Lower jaw. Normally, the sutures in the human skull fuse after the. The Fgfr2c C342Y mutation results in. If necessary, mid-facial advancement and jaw surgery can be done to provide adequate orbital. 22q11. And I have to say that Figgerits is a crossword reinvention. 42 The term “Crouzon syndrome” describes an autosomal disease, which results from hereditary mutations identified in specific genes in the human DNA chain. Affected individuals often have a prominent forehead (frontal bossing); a curved nose; unusually flat or underdeveloped mid-facial regions (midface hypoplasia); and a short upper lip. Crouzon syndrome is a complex genetic birth disorder that may affect a child’s face, skull, and teeth. court fool. Figgerits Crouzon syndrome results in lower jaw __: PROTRUSION. Enter the length or pattern for better results. In the 1990s, for example, they learned that a mutation in one gene causes Crouzon syndrome — characterized by wide-set, often bulging eyes and an underdeveloped upper jaw — while a mutation in a different gene leads to the down-slanting eyes, small lower jaw and cleft palate of Treacher Collins syndrome. C342Y) in the FGFR2 receptor, are viable and fertile and are characterised by brachycephaly caused. Some of the symptoms of Crouzon Syndrome are. Enter the length or pattern for better results. Genetic mutations causing deficient cranial neural crest migration and proliferation can result in Treacher Collins syndrome,. Describe the differential diagnosis of Crouzon syndrome. In addition, a small, underdeveloped upper jaw (hypoplastic maxilla) with protrusion of the lower jaw (relative mandibular prognathism) may also occur. CHIN; JOWL; MANDIBLE; Likely related crossword puzzle clues. doi: 10. Some people could develop it due to poor dental extractions. Symptoms of this disorder may be: abnormalities of the skull, face and brain due to premature closure of the bones of the skull; swelling of the optic disk inside the eye; impaired vision; hearing loss; a beaked- shaped nose; an underdeveloped lower jaw; and/or a high arched palate. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. The Crossword Solver found 30 answers to "Lower jaw bones", 9 letters crossword clue. G. twist. Crouzon syndrome is a rare genetic condition affecting primarily the skull and facial bones. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. He described the triad of calvarial deformities, facial anomalies, and exophthalmos. 05 for height; p < 0. Deformed or misshapen head with the head being wide across the front and short from front to back; Bulging wide-set eyes; Facial bone deformities; Jaw deformities like a protruding lower jaw; Sleep Apnea; Problems breathing due to facial deformities caused by Crouzon Syndrome. It makes up approximately 4. The Crossword Solver found 30 answers to "A jaw or jawbone (8)", 8 letters crossword clue. How Is Crouzon Syndrome. Clue: Lower jaw. ) Figgerits and the link to the main level Figgerits answers level 28. He had hydrocephalus since infancy and recently suffered from frequent dizziness. Crouzon syndrome pathogenesis and currently 60 different mutations have been identified, out of which 95% muta-tions occur in exon 8 and 10 of this gene in Crouzon syn-drome (Yang et al. This can lead to the following: Apert syndrome: Children with Apert syndrome have underdeveloped facial features, pressure in the skull, bulging eyes, and webbed fingers or toes. we have prepared a compeling topic for you. Cohen (1973) provided a review of all the. Signs of Crouzon syndrome include: abnormal face shape. 8% of all cases of craniosynostosis. Crouzon Syndrome (CS), Pfeiffer syndrome (PS) and the phenotypically related Jackson-Weiss (JW) variant are three craniosynostotic conditions caused by heterozygous mutations in Fibroblast Growth. Apert syndrome treatments include: Eyedrops during the day, with. In Crouzon syndrome, the bones in the skull and face. Core Tip: Crouzon syndrome (CS) is an autosomal dominant inherited craniofacial disorder caused by mutations in fibroblast growth factor receptor 2, but approximately 50% of cases result from de novo mutations. Less commonly, there is a mutation of the FGFR3 gene which results in Crouzon syndrome syndrome with acanthosis nigricans. Objective. This early fusion prevents the skull from growing normally and affects the shape of the head and face. Lower jaw. The mean age at the time of review was 11. What causes Crouzon syndrome? Crouzon syndrome is a genetic condition, caused by a mutation (change) on a specific gene. Mayo Clinic notes this type of procedure is appropriate for children once their jaw growth stops, at about 14 to 16 years of age for females and 17 to 21 for males. His eye sockets were shallow causing the eyes to appear very bulging. Here are the possible solutions for "Result" clue. Premature fusion of the skull bones prevents the skull from growing normally and affects the shape of the child’s head and face. Enter a Crossword Clue. The Crossword Solver found 30 answers to "front of lower jaw 4", 4 letters crossword clue. Representation in media — like Selma Blair's openness about her MS — also goes a long way. Symptoms. Its mutation will therefore cause a acceleration of the ossification process of all. Bones in the face may also be fused together, resulting in a flat midface and protruding eyes. It is a disorder caused by mutations in a specific gene — the fibroblast growth factor receptor 2 (FGFR2) gene. Premature fusion of skull bones happens during Crouzon syndrome. The Crossword Solver found 30 answers to "Lower jaw bones", 9 letters crossword clue. Current Environment: X. Crouzon’s syndrome, also known as brachial arch syndrome, is an autosomal dominant disorder with complete penetrance and variable expressivity. Techniques to encourage bone growth may be used. You can easily improve your search by specifying the number of letters in the answer. Abstract. 75 for right eye, +5. The Crossword Solver found 30 answers to "of the jaw", 7 letters crossword clue. Inheritance is autosomal dominant, resulting from mutations in the Ig II-III linker region of the FGFR2 gene. Here are the possible solutions for "Lower jaw" clue. Result Crossword Clue Answers. They fuse together during adulthood when growth stops. 0. We found 20 possible solutions for this clue. Abstract. Click the answer to find similar crossword clues . 2 Case Report A 4-year-old female patient reported with the chief complaint of protrusion of lower jaw. Described by a French neurosurgeon in 1912, it is a rare genetic disorder. Fewer than 70 cases have been described in the medical literature. Click the answer to find similar crossword clues . A key feature of Crouzon is the premature closure of the skull bones, called craniosynostosis. Introduction. Enter the length or pattern for better results. In Crouzon syndrome, the boundaries that join the bones of the skull (sutures) to close earlier than they typically do. Research has identified the affected genes as theCrouzon syndrome, also known as craniofacial dysotosis, is a genetic syndrome in which the seams of the skull fuse in abnormally. In the Crouzon mandible, the ascending and descending heights, effective and mandibular. Click the answer to find similar crossword clues . which results in hydrocephalus and venous dilation of the. The Crossword Solver found 30 answers to "of the jaw", 7 letters crossword clue. Basal cell nevus syndrome. Abnormal growth of these bones leads. Poole MD, Ashworth GJ, Hockley AD, Hayward RD, David DJ, Pulleyn LJ, Rutland P, et al. If certain letters are known already, you can provide them in the form of a pattern. Crouzon syndrome is a genetic congenital condition characterized by skeletal and facial malformations. Ninety-one computed tomography scans were included (12 Asian Crouzon syndrome patients, 22. In the 1990s, for example, they learned that a mutation in one gene causes Crouzon syndrome — characterized by wide-set, often bulging eyes and an underdeveloped upper jaw — while a mutation in a different gene leads to the down-slanting eyes, small lower jaw and cleft palate of Treacher Collins syndrome. Today's crossword puzzle clue is a quick one: Lower jaw. charges (4) Crossword Clue. Enter the length or pattern for better results. It is a genetic autosomal dominant disorder, caused by mutations of the FGFR2 (fibroblast growth factor receptor), or by less common FGFR3 genes. [ 2, 3] The major division among craniosynostoses is between the nonsyndromic and. Enter the length or pattern for better results. Differential Diagnoses. Click the answer to find similar crossword clues . com.